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首页> 外文OA文献 >The Bacterial Insertion Sequence Element IS256 Occurs Preferentially in Nosocomial Staphylococcus epidermidis Isolates: Association with Biofilm Formation and Resistance to Aminoglycosides
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The Bacterial Insertion Sequence Element IS256 Occurs Preferentially in Nosocomial Staphylococcus epidermidis Isolates: Association with Biofilm Formation and Resistance to Aminoglycosides

机译：细菌插入序列元素IS256优先出现在医院表皮葡萄球菌分离株中：与生物膜形成和对氨基糖苷的抗性相关。

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Staphylococcus epidermidis is a normal constituent of the healthy human microflora, but it is also the most common cause of nosocomial infections associated with the use of indwelling medical devices. Isolates from device-associated infections are known for their pronounced phenotypic and genetic variability, and in this study we searched for factors that might contribute to this flexibility. We show that mutator phenotypes, which exhibit elevated spontaneous mutation rates, are rare among both pathogenic and commensal S. epidermidis strains. However, the study revealed that, in contrast to those of commensal strains, the genomes of clinical S. epidermidis strains carry multiple copies of the insertion sequence IS256, while other typical staphylococcal insertion sequences, such as IS257 and IS1272, are distributed equally among saprophytic and clinical isolates. Moreover, detection of IS256 was found to be associated with biofilm formation and the presence of the icaADBC operon as well as with gentamicin and oxacillin resistance in the clinical strains. The data suggest that IS256 is a characteristic element in the genome of multiresistant nosocomial S. epidermidis isolates that might be involved in the flexibility and adaptation of the genome in clinical isolates.
机译：表皮葡萄球菌是健康人类微生物群的正常组成部分，但它也是与使用留置医疗设备相关的医院感染的最常见原因。来自设备相关感染的分离株以其明显的表型和遗传变异性而闻名，在这项研究中，我们寻找了可能有助于这种灵活性的因素。我们表明，表现出自发突变率升高的突变体表型在致病性和共生表皮葡萄球菌菌株中均很少见。然而，该研究表明，与普通菌株相反，临床表皮葡萄球菌菌株的基因组携带多拷贝的插入序列IS256，而其他典型的葡萄球菌插入序列（例如IS257和IS1272）在腐生菌之间均等分布和临床分离株。而且，发现IS256的检测与临床菌株中生物膜的形成和icaADBC操纵子的存在以及庆大霉素和奥沙西林的耐药性有关。数据表明，IS256是多抗性医院表皮葡萄球菌分离株基因组中的一个特征性元素，可能与临床分离株中基因组的灵活性和适应性有关。

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